2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N3121
    Pachypodol 33708-72-4 ≥99.0%
    Pachypodol is an orally active methoxyflavonoid compound. Pachypodol activates the ERK-dependent Nrf2 pathway and inhibits Apoptosis. Pachypodol exhibits activities such as antioxidant, cytoprotective, anti-inflammatory effects. Pachypodol improves cognition. Pachypodol exerts protective effects against cardiac and liver damage. Pachypodol has anticancer activity against colon cancer.
    Pachypodol
  • HY-N4090
    Vicenin 3 59914-91-9 98.77%
    Vicenin 3 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=46.91 μM) from the aerial parts of Desmodium styracifolium.
    Vicenin 3
  • HY-N7004
    Arborine 6873-15-0 99.80%
    Arborine inhibits the peripheral action of acetylcholine and induces a fall in blood pressure.
    Arborine
  • HY-N7354
    Quininic acid 86-68-0 ≥98.0%
    Quininic acid, purified from Eucalyptus globulus, cinchona bark, and other plant products, is the most abundant organic acid.
    Quininic acid
  • HY-N7607
    Quercetin-3-O-D-glucosyl]-(1-2)-L-rhamnoside 143016-74-4 99.00%
    Quercetin-3-O-D-glucosyl]-(1-2)-L-rhamnoside is main antioxidant from Shuxuening, an herbal medicines injection.
    Quercetin-3-O-D-glucosyl]-(1-2)-L-rhamnoside
  • HY-P0083
    Ornipressin 3397-23-7 99.63%
    Ornipressin is a potent vasoconstrictor, hemostatic and renal agent. Ornipressin is also a vasopressin agonist specificly targeting to V1 receptor.
    Ornipressin
  • HY-P0303
    Crustacean cardioactive peptide，free acid 309247-84-5 99.44%
    Crustacean cardioactive peptide, free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide, free acid also modulates the neuronal activity in other arthropods.
    Crustacean cardioactive peptide，free acid
  • HY-P1440
    BeKm-1 524962-01-4 99.51%
    BeKm-1 is a HERG (human ether-a-go-go-related gene) blocking compound. BeKm-1 can be used for the research of heart disease.
    BeKm-1
  • HY-P1888
    HIF-1 alpha (556-574) 1201633-99-9 99.37%
    HIF-1 alpha (556-574) is a short hypoxia-inducible factor-1 (HIF-1) 19 residues fragment. HIF-1 functions as master regulator of response to oxygen homeostasis.
    HIF-1 alpha (556-574)
  • HY-P1918
    Activated Protein C (390-404), human 146340-20-7 99.01%
    Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity.
    Activated Protein C (390-404), human
  • HY-P2232
    Conalbumin 1391-06-6
    Conalbumin (Ovotransferrin), also known as ovotransferrin, is a monomeric glycoprotein consisting of 686 amino acids, encoded by the avian transferrin gene in the oviduct, and a prominent component of chicken egg white. Exhibiting a unique glycosylation pattern that differentiates it from serum transferrin, Conalbumin is a potent iron binder that plays a crucial role in iron transport to developing embryos. Additionally, it possesses a range of biological activities, including antimicrobial, antifungal, antiviral, anticancer, antioxidative, antihypertensive, and immunoregulatory properties, making it valuable in numerous applications such as infant formula ingredients, food additives, and agents for enhancing animal health.
    Conalbumin
  • HY-P2249
    ELA-21 (human) 2245073-05-4 98.92%
    ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways.
    ELA-21 (human)
  • HY-P3751
    [Tyr8] Bradykinin 32222-00-7 99.61%
    [Tyr8] Bradykinin is a B2 kinin receptor agonist. [Tyr8] Bradykinin also stimulates ERK1/2 phosphorylation. [Tyr8] Bradykinin can be used as an internal standard.
    [Tyr8] Bradykinin
  • HY-Y1620
    3-(3,4-Dimethoxyphenyl)propanoic acid 2107-70-2 ≥98.0%
    3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies and other anemias.
    3-(3,4-Dimethoxyphenyl)propanoic acid
  • HY-100276
    Naminidil 220641-11-2 99.62%
    Naminidil is a cyanoguanidine KATP opener.
    Naminidil
  • HY-100933
    MY-5445 78351-75-4 ≥99.0%
    MY-5445 is a specific inhibitor of the cyclic GMP phosphodiesterase, phosphodiesterase type 5 (PDE5), with a Ki of 1.3 μM. MY-5445 inhibits human platelet aggregation. MY-5445 is a selective modulator of ATP-binding cassette (ABC) transporter ABCG2, with anti-proliferative effect.
    MY-5445
  • HY-100960
    Dioctanoylglycol 627-86-1 ≥98.0%
    Dioctanoylglycol (Ethylene glycol dicaprylate), a diacylglycerol analog, is a diacylglycerol kinase (DGK) inhibitor (Ki of 58 μM).
    Dioctanoylglycol
  • HY-101172
    RS 23597-190 149719-06-2 ≥98.0%
    RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose.
    RS 23597-190
  • HY-103061
    Dehydro-ZINC39395747 433248-87-4 99.20%
    Dehydro-ZINC39395747 is a derivative of ZINC39395747. ZINC39395747 is a potent cytochrome b5 reductase 3 (CYB5R3) inhibitor with an IC50 of 9.14 μM and a Kd of 1.11 μM. ZINC39395747 can increase NO bioavailability in vascular cells.
    Dehydro-ZINC39395747
  • HY-103263
    PSB-06126 1052089-16-3 99.86%
    PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the Ki values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC50 value of 7.76 μM and a Ki value of 4.39 μM.
    PSB-06126
Cat. No. Product Name / Synonyms Application Reactivity